SIANOKOBALAMINA (WIKAMINA B12)
ʻAno a me nā Waiwai
He kristal ʻulaʻula a pauka kristal paha kēia huahana, ʻaʻohe ʻala, ʻaʻohe ʻono a he mau waiwai hoʻoulu wai ikaika. Hoʻoheheʻe iki ʻia i ka wai a i ʻole ka ethanol, ʻaʻole hoʻoheheʻe ʻia i ka chloroform a i ʻole ether. Kūpaʻa i ka wela, akā hiki ke lilo i mea pono ʻole ke hōʻike ʻia i nā mea oxidizing a i ʻole nā mea hōʻemi, nā paʻakai metala kaumaha a me nā waikawa ikaika a me nā alkalis ikaika.
ʻAno Kemika
ʻO ka Vitamin B12 kahi hui equioctaphedral e loaʻa ana nā ion cobalt. ʻO kona ʻano kikowaena he apo corrin pālahalaha i haku ʻia me ʻehā pyrroles i hoʻopili ʻia. ʻO nā molekala o ka vitamin B12 ua hana ʻia me 3 mau ʻāpana: he apo gourin i chylated ʻia e ʻehā mau ʻātoma N a me nā ion cobalt waena; 5,6-dimethylbenzimidazole i hoʻopili ʻia i nā ʻātoma N-7 a me nā ion cobalt e like me nā molekala vitamin B 12 o nā ligands haʻahaʻa. Eia kekahi, ua pili pū ʻo DMBI i ka aminopropanol ma o nā hui phosphate, a ua pili pū ʻo aminopropanol i ke kaulahao ʻaoʻao propionic acid ma ka pyrrole D; hui adenosyl a i ʻole ka hui methyl Ua pili ia me nā ion cobalt e hana i ka ligand luna o nā molekala vitamin B12.
Hana Kino
Hiki i ka hemahema o ka Vitamin B12 ke alakaʻi i ka neuritis peripheral. ʻO nā hōʻike mua o ka hemahema o ka Vitamin B12 i nā keiki he ʻano maʻamau ʻole, ka lohi o ka helehelena, ka lohi o ka pane ʻana, a ma hope loa e alakaʻi ai i ka anemia. Hoʻolaha i ka ulu ʻana a me ka oʻo ʻana o nā hunaola koko ʻulaʻula. Hoʻololi ʻia ka Methylpropandiyl coenzyme A i succinoyl coenzyme A a komo i loko o ke kaʻina hana tricarboxylic acid, kahi e pili ai ka succinyl coenzyme A i ka synthesis o ka heme. Komo pū ka Vitamin B12 i ka synthesis o ka deoxynucleic acid (DNA), ka metabolism o ka momona, nā kalapona a me ka protein, a hoʻonui i ka synthesis o nā nucleic acid a me nā protein.
